Granulomatous drug eruption associated with imipramine
نویسنده
چکیده
GA: granuloma annulare IGDR: interstitial granulomatous drug reaction INTRODUCTION Granulomatous drug eruptions are rare and include interstitial granulomatous drug reaction, drug-induced granuloma annulare, drug-induced accelerated rheumatoid nodulosis, and druginduced sarcoidosis. The differential diagnosis is broad and includes granuloma annulare, lichen planus, connective tissue disease, sarcoidosis, and mycosis fungoides. Diagnosis is, therefore, best established with tissue examination of a punch biopsy specimen and correlation with clinical history. Imipramine is a tricyclic antidepressant that is used to treat depression as well as enuresis. It is widely used in medicine but not previously reported to cause a granulomatous drug eruption. Herein we report the first case, to our knowledge, of a granulomatous drug eruption associated with imipramine.
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